Great Gatsby and Hamlet comparision Essay

Throughout both books GG and H, there are several discrepancies between appearances vs. reality. It appears that everyone is full of deception and ulterior motives. Tom, Daisy and Gatsby all appear innocent and happy from an outsider’s perspective but when given a closer look the imperfections shine bright†¦. Hamlet is based aroundcharacters that play their roles behind the veil of duplicity. Everything appears to be true and accurate, but in reality it’s vice-versa. Three of the main characters that hid behind the mask are Hamlet, King Claudius, and Polonius. From behind this mask, their appearance is genuine and sincere, whereas in reality, they’re plagued with lies. They often appear to be only one way whilst they really are something entirely different. By viewing the controversies going on in Denmark, it is justifiable to state that there is truly something rotten in the state of Denmark. BP#1 Polonius and Tom -P appears loyal; reality sly and selfish. P appears to care about his family when in reality he is only concerned of how his kid’s actions reflect back on him. Right before Laertes leave for France P â€Å"Neither a borrower nor a lender be: For loan oft loses both itself and friend; And borrowing dulls the edge of husbandry.†This is typically fatherly advice, but later it is realized that P doesn’t trust L when he sends someone to spy on him. P actions may seem genuine but later they prove no more than P worried about his son’s reflection upon himself. -Like P, T appears to be a loyal man especially to his family, when in reality he is extremely disloyal to D. â€Å"Tom’s got some woman in NY†. Tom is not happy w his marriage as he feels the need to cheat. At the dinner table, D quickly brings up how she has a bruised finger and is in pain â€Å"That’s what I get for marrying a brute of a man, a great big hulking-â€Å". T has told D not to call him â€Å"hulking†, her defiance to her husband shows how unhappy she is w their marriage. Both P and T appear to be loyal from an outsider’s perspective but in reality they both portray selflessness and carelessness towards their families. BP#2 Claudius and Daisy -Claudius appears innocent, upset about his brother’s death and concerned for Hamlets well being. Claudius in reality is multi-faced and his ambition is to aquire the crown by killing his brother and marries his sister in law.  Claudius fears that H is going to discover what he has done and come after him. He investigates H madness by saying he is worries about H. â€Å"Whose whisper o’er the world’s diameter, as levels as the cannon to his blank transports his poisoned shot, may miss our name and hit the woundless air. Oh come away! My soul is full of discord and dismay†. D appears innocent and happy w her life; reality is she is married T because of status and is therefore unhappy. Even though she is unhappy w her marriage it is clear that status means a lot to her, especially when she is with Gatsby and he is showing her all his expensive items â€Å"It makes me sad because I have never seen such nice shirts before†. Daisy also says â€Å"Of love, of money, of unquestionable practicality† it was practical for her to marry T but this quote also suggests that T bought her. Both C and D married to achieve a higher status and for the betterment of themselves. They both achieved higher status and by doing this prove that they married out of greed than love. BP#3 Gatsby and Hamlet G appears rich, well educated (G believes that a man’s education is what categorizes the lower class from the upper class) and innocent; reality became rich through illegal means; bootlegging, is not educated and desperately wants D. â€Å"I’ll tell you Gods truth†¦I am the son of some wealthy people in the middle-west† as a result his family background is an ex. Of the false appearance G portrays. He mourns so deeply regarding the death of his father and his mother’s remarriage with his uncle that he appears insane, yet in reality he takes the advantage of his insanity to avenge his father’s wrongful killing. Another reason is, his love for Ophelia. He is deeply hurt due to the ignorance of Ophelia that he uses it to advantage, by showing hate towards her, in order to make others think that his madness is due to his rejected love. He uses his madness to manipulate and deceive the other characters, while in reality he is carrying out his master plan. He plays his role extremely well by showing his madness that he is able to convince Polonius that it’s all due to his rejected love, Ophelia. â€Å"He knew me not at first; he said I as a fishmonger: he is far gone, far gone: and truly in my youth I suffered much extremity for love; very near this.† –P is reporting to C that H is insane Both H and G are tragic heroes. Hamlets flaw being his procrastination and Gatsby’s flaw is his belief that you can  relive the past. Both characters are blinded by the thing they want most and the obsession with it fuels their actions causing both characters to take it so far that they end up hurting themselves and others around them in their recklessness.

The Importance of Ethics Committees

Health care institutions operate to uphold the rights and well-being of patients. In practicing patient care, members of health care organizations face actions and decisions that should be aligned with ethical issues maintained by health care facilities, such as hospitals, to look after the best interests of patients. To oversee the ethical issues that health care facilities should observe consistently, establishing ethics committees is necessary.In order to determine the importance of ethics committees in the field of health care and medicine, it is relevant to go over the history of the establishment of ethics committees, the varied and significant roles played by ethics committees in health care and medicine, the principles upheld by ethics committees, and the magnitude of ethics committees in health care facilities and the field of medicine. Ethical issues frame health care and the field of medicine.Health care ethics is primarily based on principled obligations that health care and medicine should provide for human beings, as well as the binding obligations to constitutional laws. Health care ethics ensure that health care policies, services, programs, and practices are in line with moral obligations to human beings and political obligations to the state, while keeping in mind the sole purpose of health care and medicine – to improve the quality of life.With the unending and increasing issues and choices that members of health care organizations and the field of medicine must face and decide on each day, there is a need to put up ethical standards and norms to abide by to avoid inconsistencies, conflicts, and disagreements. The requirement for ethics committees was formalized in 1992 by the Joint Commission (O’Reilly, 2008). Ethics committees are composed of various members of health care institutions. Members of ethics committees include â€Å"physicians, nurses, psychologists, lawyers, administrators and supervisors, families, and the comm unity† (Fremgen, 2005).Ethics committees are in charge of overseeing practices and operations within health care facilities regarding the services provided for patient care. Primarily, ethics committees in contributing or improving health care policies employed by facilities by thorough analysis and research and the formulation of ethical procedures or guidelines that the health care facility and all its members must observe at all times. These procedures or guidelines are patient-centered – one which puts forth the best interest of the patient.Ethics committees uphold ethical health care principles and practices by intervening in conflicts within the health care facility, especially when it comes to decision-making and ethical issues. The ethics committee reexamines a particular situation and arrives at a counsel or a suggestion as to how the parties involved will go about solving the problem. The result of the ethics committee’s reexamination is based on ethica l laws and principles endorsed by the state and the health care facility to put the patient’s concerns above all.In some instances, the ethics committee also reviews the quality and kind of health care services received by the patient in order to determine whether it was based on guiding ethical principles or not. (Fremgen, 2005) Ethics committees are influential in determining the fairness, reliability, morality, and integrity of health care facilities. It serves as a quality control committee, keeping health care services, practices, and operations in check, in order to make sure that they comply with ethical principles related to health care and medicine.Through ethics committees, health care facilities are able to sustain a mission, vision, goals, and objectives that are within the limits of what is ethical for health care facilities to provide. This ensures that the quality of health care services provided to patients meet their needs, demands, and expectations and it de fends what is morally upright in relation to patient care. Ethics committees keep professionalism in the work place in check, and it guides major ethical choices and decisions in the field of health care and medicine.With the realization of the significant roles and responsibilities that ethics committees carry out, it is therefore of great importance to health care facilities or organizations to establish an ethics committee that will serve as a consultant or a guide in putting health care practices and operations in line with ethical laws and principles. It does not only add value or integrity to health care facilities, but it also ensures that patient care is provided for, qualitatively and ethically.

Behaviourists Explain Maladaptive Bbevaviour in Terms

ESSAY TITLE: â€Å" BEHAVIOURISTS EXPLAIN MALADAPTIVE BEHAVIOUR IN TERMS OF THE LEARNING PRINCIPLES THAT SUSTAIN AND MAINTAIN IT. DISCUSS THIS STATEMENT AND SHOW HOW A BEHAVIOURIST’S APPROACCH TO THERAPY IS IN STARK CONTRAST TO A PSYCHOANALYTIC ONE† Behaviourism is a movement within psychology that works on the principle that all behaviour is â€Å"learned† , that we were all born with a â€Å"blank slate†.Behavioural approaches use strict experimental measures to study observable behaviour ( or responses ) in relation to the environment, thus resulting in the maladaptive behavioural approaches that we employ to deal with our learning. Behaviourism was first developed in the early 20th century by an American psychologist John B Watson, who at the time was working in the field of animal psychology. He believed that all behaviour was observable and therefore scientific, and worked on the principle and study of the association between a stimulus and response. Watson did not deny the existence of inner experiences, but insisted that they could not be studied because they were not observable ) Watson’s stimulus and response theory of psychology claimed that all complex forms of behaviour – emotions, habits etc – are seen as composed of simple muscular and glandular elements that can be observed and measured, and that emotional reactions are learned in much the same way. Watson aimed to prove his beliefs with laboratory experiments, and one of these experiments was known as â€Å" The Little Albert Experiment†.Little Albert was a small young boy of about 18 months of age , Young Albert would sit happily on the floor and play with a white rat. Young Albert did not like loud noises, and on the presentation of the rat, scientists would clang two metal rods together behind Young Albert’s head, which resulted in screaming from young Albert. The result of this â€Å" conditioning† experiment was that Alb ert came to associate the rat with fear, and on following presentations of the rat, young Albert displayed considerable fear.Around the turn of the 20th century, another American psychologist Edward Lee Thorndike, investigated how animals learn, in one experiment he placed a cat in a â€Å"puzzle box† and measured the time it took to escape. Over a number of trials, the time taken to escape decreased, and from this observation he developed the â€Å"law of (positive) effect†, which states that any behaviour leading to a positive outcome will tend to be repeated in similar circumstances. If we like the consequences of our actions then the actions are likely to be repeated, this ype of learning was known as operant conditioning . Thorndike’s work was developed by such behaviourist’s such as B. F. Skinner. Skinner approach to psychology was scientific, his views came from Darwin’s theories of evolution. Skinner focused on the environment as a cause fo r human behaviour, he did not think that people acted for moral reasons, believing they reacted in response to their environment. For example: a person might do a good thing not for moral reasons, but for the rewards received for the act.Skinner believed that the mental process was irrelevant. To prove his theories skinner invented what is now referred to as the â€Å" skinner box†. This was a small box with a lever mechanism inside that dispensed a food pellet when pressed. Many experiments were done using this box system, and in one of these experiments a rat was rewarded with a food pellet on every press of a lever ( condition A). In another condition ( condition B ) the rat was only rewarded with a food pellet only sometimes when pressing the lever.They found that rat B pressed the lever much more! Why was this? Because the lever pressing was only occasionally rewarded, it took longer to figure out that in no longer worked. Skinner believed that reinforcement is a key con cept in behaviourism, that it increases the likelihood that an action will be repeated in the future, however, punishment on the other hand, will reduce the likelihood that an action will be repeated. For example: shouting at a child who is behaving in an irritating way, might in fact lead to the behaviour appearing more frequently.The shouting therefore, is seen as reinforcing( providing attention) rather that punishing. Ivan Pavlov was a Russian physiologist who studied the digestion of dogs, he found that laboratory dogs would salivate at the sight of a food dish, from this he reasoned that the dogs learned an association between the dog bowl and the food it usually contained. In behavioural terms the food ( the unconditioned stimulus or UCS) had been associated with the bowl ( the conditioned stimulus or CS) giving rise to the conditioned response or CR of the dog salivating at the sight of the bowl.In these terms the unconditioned response or UCR would be the dog salivating at the sight of food. In further experiments a bell was continually rung immediately before feeding, Pavlov was able to condition a dog to salivate whenever a bell was rung. After a period of conditioning, Pavlov discovered the dog would salivate at the sound of a bell even if no food was forthcoming, and by pairing the conditioned stimulus of the bell with a light, he could get the dog to salivate at the presentation of the light only, even though the light and the food had never been presented together.This type of conditioning demonstrates how readily behaviour will form predictive associations. This learnt behaviour was called classical conditioning. In terms of human behaviour classical conditioning involves involuntary behaviour such as a fear response, they can be elicited, meaning you can do something that produces an involuntary response. Operant conditioning involves voluntary behaviours. Voluntary behaviours are those that cannot be made to happen, meaning that you cannot ge t those behaviours until someone carries them out.Behavioural approaches assume that what is learned may be unlearned, and explains why phobias tend to get worse as time goes on. When you meet you fear, your fear level rises (fight)and so does your level of adrenaline. If you avoid the fear ( flight) you will reduce the fear and your level of adrenaline. This is the connection between your fear and your response to it. The result from this is a maladaptive behaviour, often with an avoidance and a rise in anxiety levels, leading to stress and other ways of behaviour and coping strategies.Social learning theory is another approach to behaviourism of Albert Brandura , it emphasizes the importance of observing and modelling behaviours, attitudes, and emotional reactions of others, Brandura pointed out that much of what we learn is in the consequence of observation, indirect rewards/punishments and modelling. (www. psychology. org) What are the behavioural approaches to therapy? Behaviou ral therapy concentrates on taking away the old responses or conditioning new ones, there are a number of techniques that can be used: * Systematic desensitisation ( experiences in imagination) * In vivo exposure ( experiences in reality)The way in which these techniques work is that it is difficult to feel two opposing states at the same time ie, relaxation and fear. The client will be coached in relaxation techniques and then encouraged to remain relaxed whilst imagining themselves in a mildly frightening situation, once able to do this, they will be encouraged to imagine themselves in a more slightly distressing situation and so on. * Flooding Flooding is a behavioural technique that relies on the idea that it is not possible to maintain a state of fear indefinitely.Flood therapy will expose the client to the fear / situation until their fear drops to normal, the idea that when released from that fear their fear level will drop to a normal and acceptable tolerance. * Selective re inforcement This is based on operant conditioning, and for example: in schools and at home any good behaviour is reinforced by means of reward. * Modelling This makes use of observational learning, the client will watch the therapist/teacher and copy what they do. This gives the opportunity to view adaptive behaviour on which to base a new response. * Cognitive behaviourThis is another approach to psychology, the origin of the word â€Å" cognitive† comes from Latin, which means to â€Å"know and understand†. This perspective is directly linked with the internal mental processes of thought, such as memory, problem-solving, thinking and language. The cognitive psychological perspective is seen as a response to behaviourism because cognitive psychologists see humans as rational beings and not as programmed animals with no ability to think. The study of the mental processes is not observable, which does contrast with â€Å" traditional behaviourists ideas†, which i s to study only observable ways.The focus of cognitive psychologists is the way the brain processes information ( stimuli) received ( input ) which leads to a certain behaviour ( output ). This process is often compared with the computer function, however this comparison is not too coherent because the human mind/brain, is far more advanced than a computer. Humanistic psychologists see this approach as cold because the cognitive psychologists ignore any emotions any individual may have, and may well prove everything in a way that is too clinical.All mental processes are investigated scientifically, which is good to cognitive behaviour. (I apologize that i slightly went off track with the reference to the humanistic approach, but i felt it very relevant to compare a behavioural approach with the humanistic approaches such as Maslow and Rogers) There is a belief in behavioural therapy that human behaviour does not just happen, but is caused by environmental events that cannot be contr olled, and this has been criticised by other approaches for ignoring learning due to evolution.This can also be said about human behaviour and the relevance to food, diet and nutrition. It is a known fact certain foods have chemicals that do alter one’s behaviour, and in the day’s of food being tampered with and injected with growth hormones, one has to be aware of this. It is now at this point in the essay that i will turn to the view of the psychoanalytic one and their view to the behavioural approach in therapy. Psychoanalytic approach to behaviourism One thing that is certain, and that few textbooks of psychology ignore Freud and many are built around his theories† â€Å"Freud’s approach was as logical and his findings as carefully tested as Pavlovs† â€Å"The foundation of Freud’s method-psychic determination and the relentless logic of free association are scientific† â€Å"Freud’s method was to take everything anybody sa id at any time or place regardless of truth or falsity in terms of external reality to be used as basic data in revealing the dynamics of the personality† â€Å"Freud devised a means of diagnosing man’s troubles, not of suppressing them, and the emotions we suppress are the mental equivalents that all is not well within the body† (Freud and the Post Freudians. J. A. C. Brown) Freud, first published his psychoanalytic theory of personality in which the unconscious mind played a crucial role. Freud combined the then current notions of consciousness, perception and memory with the ideas of biologically based instincts, to make a new theory of psychodynamics. Freud’s theory, which forms the basis of the psychodynamic approach, represented a major challenge to behaviourism. Freud’s theory of personality was based on the assumption that all behaviour stems from the unconscious mind.He divided the personality into three different parts, that of the id, the ego and the super-ego, which Freud believed were often in conflict with each other. * The id operates on the pleasure principle seeking immediate gratification. * The ego obeys the reality principle and plans for the future * The super-ego is conscious and makes us aware of our moral standards Freud believed that we all have a stream of psychic energy, he called this constant psychic energy the libido, reflecting that the sex drive was a primary life instinct. If this energy was suppressed, the energy would seek out another outlet, such as in dreams and/or neurotic behaviour. Freud believed we go through several personality developmental stages in the early years of life.He called these stages the psychosexual stages. During each of these stages the pleasure seeking impulses of the id focus on a particular part of the body. The first year of life Freud called the oral stage, whereby babies derived pleasure from sucking and/or nursing. The second stage was termed the anal stage, and Freud believed infants derived pleasure from withholding and expelling faeces. The next stage was the phallic stage where the child derived pleasure from his or her genitals. During the phallic stage the child reached a conflict called the oedipal conflict , whereby Freud believed the anxiety caused was the basis of all later anxieties.The oedipal conflict resolved at the latency period, which lasted from the age of seven to twelve, and during this time children became less concerned with their bodies and turned their attention to life skills, and finally adolescence and puberty brought about the genital stage, which is the mature stage of adult sexuality. Freud placed much emphasis on child development believing that if the child at any given time was denied the gratification needed in each stage, then a maladaptive behaviour was to take place, for example: a man might be hostile towards his boss, an older co-worker, and all other â€Å"parent figures† in his life because h e is unconsciously re-enacting childhood conflicts with an overprotective parent.The psychoanalyst would help the client recognise his hidden, pent up anger toward the parent, experience it, and trace how this unconscious source of continuing anger and the defences around it have been creating problems. (Psychology Bernstein) Freud believed that many clues to the unconscious lie in the constant stream of thoughts, feelings, memories and images experienced by all people. These clues can be uncovered and understood if the client relaxes defences that block or distort the stream of consciousness. Thus, one of the most basic techniques of psychoanalysis is free association, in which the client relaxes, often lying on a couch, reporting everything that comes to mind as soon as it occurs, no matter how trivial, bizarre, or embarrassing it may seem.Clues to the unconscious may appear in the way thoughts are linked, rather than in the thoughts themselves. For example: if the client stops ta lking or claim that their minds are blank, the psychoanalyst may suspect that unconscious defence mechanisms are keeping threatening material out of the consciousness. The interpretation of dreams is another one of Freud’s ideas, and psychoanalysts believe that dreams express wishes, impulses and fantasies that the dreamer’s defences keep unconscious during waking hours. The psychoanalyst will look at the client’s thoughts and behaviours, and will help the client to become aware of all the aspects of their personality, including the defences and the unconscious material behind them.The basic strategy is to construct accurate accounts of what has happened to the client ( but has been â€Å" forgotten†) and what is happening to the client ( but is not understood), and in this way help the client to see their maladaptive behaviour towards their life. â€Å"The psychodynamic approach emphasizes internal conflicts, mostly unconscious, which usually pit sexual or aggressive instincts against environmental obstacles to their expression†( Psychology Bernstein) â€Å"The psychodynamic approach holds, that all behaviour and mental processes, reflect constant and mostly unconscious struggles within each person. Usually these struggles involve conflict between the impulse to satisfy instincts or wishes( for food, sex or aggression for example ) and the restrictions imposed by society.From this perspective, a display of violence ( or hostility, or even anxiety)reflects the breakdown of civilizing defences against the expression of primitive urges â€Å"(Psychology Bernstein) â€Å" the psychodynamic approach assumes that if clients gain insight into underlying problems, the symptoms created by those problems will disappear† ( Psychology Bernstein) Conclusion Although there are clear divisions in these two approaches, there is a case that the perspectives and the research, have contributed a great deal to understanding human behav iour. Therefore it is worth remembering that psychology is a dynamic science and new theories and experiments are conducted every day.As technology advances so does the field of psychology, and the study of human behaviour needs to be with the use of all the approaches that are available, whether it be behaviourism, psychoanalytic, psychodynamic, Jungian, humanistic, integrated or whatever the approach that is being used. After all, we are all unique, and one cap certainly does not fit all! However, because the classical psychoanalytic treatment may require as many as three to five sessions per week, usually over several years the cost is of consideration both in private practice and within the national health system, and this may well reflect the reason why the behavioural approach of CBT/REBT is widely used within such quarters. ( Psychology Bernstein) REFERENCES First steps in counselling Sanders 2010 Freud and the Post Freudians J. A. C. Brown 1985 www. psychology. org Psycholog y Third Edition Bernstein, Stewart, Roy, Srull, Wickers 1994

Technology Management Essay Example | Topics and Well Written Essays - 750 words - 2

Technology Management - Essay Example In current era of technology, an important asset of the organization is technology. Strategy and planning considerations are considered to include the technology. Company objectives have direct links with the technology resources achieved through communication. There is lack of an appropriate framework that supports the technology management in a customer service organization. Organizations do not give importance to strategic significance of technology to deliver the value and competitive advantages. If a firm has adopted the information technology implementation, then at execution and controlling stages communication issues among the project participants are produced. IT project has various challenges for project managers that differ substantially from features of the non-ICT traditional assignments. Continuous advancement in technology where IT project operates has led the organization towards the considerable uncertainty and risk. Changing requirements and scope of the business firm produces the high level risk for the firm’s management (Fenech and Raffaele, 2013). In a firm, collaboration culture is not embedded with the empowerment of employees to use the advanced technology tools including the social networks, participation in a network and knowledge sharing. Employees do not post their ideas and avoid the information sharing due to lack of encouragement for technology use in the organization. Workers in the firm do not have the exclusive rights to their firm’s knowledge. Knowledge is only accumulated at top level in the firms and low level employees or workers are kept away from knowledge accumulation. A class of employees known as clerical workers who support their managers do not access the document management, emails, workflows and related activities through the software. Employees’ performance in the firm is linked associated with the technology change.

Collapse paper Essay Example | Topics and Well Written Essays - 1250 words

Collapse paper - Essay Example Economic history of the United States of America extends over a period of less than two and half centuries. Over the course of this period, the US economy had multiple series of progress and problems. The United States has grown from an alliance of thirteen British colonies with distinct economies and institutions to the unified state which nowadays accounts for more than fifth of the world economy ("Economic history of the US"). US economy today is based on three major elements. The first element is its natural resources. The continent of the United States has rich mineral resources and favorable terrain, as well as mild climate conditions. It also has broad access to the ocean and corresponding transportation routes, encompassing the coastlines of both the Atlantic and Pacific Oceans, as well as that of the Gulf of Mexico. Additional shipping routes are ensured by a host of rivers crossing the country and the Great Lakes along the border with Canada. These extensive transportation channels endorsed the economic growth of the USA, especially at early stages, and played a significant role in uniting America's 50 individual states into a full-fledged economic unit ("Economy of the United States"). The second ingredient is its human resources. USA has the third largest population in the world, which was estimated to be ca 295 mil people in July 2005 (CIA). The labor force is one of the major factor of economic growth and therefore prosperity of the country. On the other hand, country's citizens are also its biggest asset. Their welfare should be one the top of government's priorities list. Good environmental conditions and balanced habitats are essential to the welfare and health of the people, which makes environmental regulation extremely significant. The third element is industrial production and investments. USA is a home to corporations, which are complex organization governed by extensive set of rules and owned by stockholders. Boosted by the advent of mass production corporations like General Electric have been crucial in shaping the country. Using stock exchanges and financial markets American investors and banks managed to substantially increase their capital investing and withdrawing funds from profitable corporations. In the current era of globalization US investors and corporations have even larger influence on the world than ever before. ("Economic history of the US") It is essential to know these because above described components are vital in making the economy of the United States prosper. Therefore, it is imperative that the US government initiate regulation in order to preserve these valuable resources. Some regulations and policies that control these resources, however, are at times being overlooked not only by private corporations but the US government itself. Some private corporations in the USA abuse the use of natural resources, which leads to the destruction of the environment and increase in pollution, both harmful to human beings. The government, on the other hand, sometimes disregards these issues and even makes some initiatives to accelerate the economy at the expense of environmental deterioration. One of the recurring problems faced by the US government is energy. The government has been constantly seeking for appropriate means to regulate the use of energy and find new energy sources. US government has been extensively seeking for such sources as oil, nuclear

Laying Off Talent Assignment Example | Topics and Well Written Essays - 250 words

Laying Off Talent - Assignment Example The success of an organization relies on the productivity of its employees. Firstly, layoffs discourage the creation of a cohesive team of experienced employees. This causes either understaffing or introduces inexperienced employees who will slow productivity since new employees require orientation (Silzer & Dowell, 2010). Additionally, layoff is always a major factor that demoralizes employees thereby slowing the productivity of the employees. The process causes fear in the remaining employees since they begin doubting the longevity of the organization thus their social security. Such a scenario discourages the creation of a dedicated workforce capable of improving the long-term performance of the organization. Laying off employees affects the talent pool primarily by reducing the capacity of the pool. Eliminating employees implies that the talents leave the organization. This causes a smaller talent pool with fewer individuals a feature that lowers the innovativeness of the workforce. In addition, the remaining employees became too demoralized to employ creativity. Both features lower the productivity of the organization. As explained earlier, layoffs require effective management that begins with the measurement of the talent to ensure that the company lays off the most appropriate group. The organization must create a conducive environment for the employees to maximize their productivity. This way, the management determines redundant employees for layoff thereby increasing the space of operations for the most productive

Errors of metabolism (newborn screening) Essay Example | Topics and Well Written Essays - 1000 words

Errors of metabolism (newborn screening) - Essay Example (CPSP, n.d.) (Rinaldo, 1988) Various findings also suggets that this disease is genetically inherited via autosomal recessive pattern. Going deep into the molecular mechanisms of this enzyme’s expression, it was found that MCAD enzyme is expressed by ACADM(alias MCAD) gene located on chromosome 1p31. Due to a point mutation at position 985 on the gene, results is swapping of an adenine by a guanine, that results in replacement of a lysine by a glutamate residue in the protein leading to onset of disease. (Grosse, 2006; Wang SS, 1999; Matsubura, 1990). Around 80% of European individuals have at least two copies of this mutation. (Wang SS, 1999). Considering high mortality rate of 20 to 25% in undiagnosed cases, this disorder was included in the list of newborn screening programmes. (Wilson, 1999) Variation in Symptoms and Prognosis The deficiency of this enzyme is characterised by symptoms such as hypoketotic hypoglycaemia, vomiting (Egidio RJ, 1989) and hypotonia progressing t o coma. (BPSU, 2006). Other symptoms include seizures, coma, residual neurological deficits. No symptoms are exhibited at birth, except for the case when newbron screening is conducted. The symptoms show up any time between teh age of three to twenty-months; in some cases, it may show up much later. Once it is successfully diagnosed, prognosis becomes much effective by administering the patient with adequate treatment regimes (Matern, 2013). Diagnosis Prenatal-testing: Prenatal testing includes molecular genetic testing that helps in early diagnosis of the disease and thus enable the parents to be mentally aware and cautious of their child’s health. The first test includes the testing of analyses that include plasma acylcarnitines, urine organic acids and urine acylglycines. Biochemical diagnoses include the measurement of fatty acid ?-oxidation in fibroblasts as well as measurement of MCAD enzyme activity in fibroblasts and other tissues (Leydiker, 2011). Molecular Genetic t esting comprises of two methods that include Targetted Mutation Analysis and Sequence Analysis. Targetted mutation analysis a.k.a Allele specific mutation analysis involves the testing of the mutations p.Lys304Glu (985A>G) and p.Tyr42His (199C>T). Sequence analysis involves the testing of sequence variants may also include other mutations such as splice site mutations, non-sense and mis-sense mutations as well as small deletions/ insertions. This method does not target mutations identified by Targetted mutation analysis. Newborn- Screening: Newborn Screening differs from Pre-natal testing such that pre-natal testing is carried out during pregnancy and before the child’s birth, whereas the former involves the testing of the child’s health condition within first few days of birth (Matern, 2013). Tandem mass spectrometry was developed by Millington et al, for analysis of acylcarnitines in blood collected from umbilical cord as well as neonatal blood. This method proved to efficient diagnostic tool to diagnose MCAD deficiency. The simplicity and speed of the method enabled its use in everyday neonatal screening of infants (Millington, 1990; Kennedy, 2010) This tool has been widely used for screening of MCAD and has proved to be a robust, efficient tool. Newborns who are MCAD deficient have higher octanoylcarnitine levels than normal individuals; this forms an effective screening test, and has helped to decrease mortality and